What is CCL3 (MIP-1α)?

CCL3, also known as MIP-1α (Macrophage Inflammatory Protein-1 alpha), is a chemokine primarily secreted by macrophages, dendritic cells, and activated T cells. Its main role in the immune system is to recruit and activate immune cells, particularly monocytes, lymphocytes, and natural killer (NK) cells, to sites of infection or inflammation. CCL3 also enhances immune responses by promoting cytokine production and facilitating cell-to-cell communication, playing a crucial role in both innate and adaptive immunity.