The CCL4 chemokine plays a role in inflammation and chemotaxis. CCL4 is produced by a variety of cells, including monocytes, NK cells, and T cells. It binds to CCR5. This receptor is expressed by T cells and macrophages (among others). CCL4 is involved in the host response to a wide range of pathogens, it's been especially studied in HIV. Furthermore, dysregulation of CCL4 expression has been associated with various pathological conditions, including autoimmune diseases and cancer. CCL4 is also named macrophage inflammatory protein-1β (MIP-1β).
| Alternative analyte names: | C-C motif chemokine ligand 4, CCL4, macrophage inflammatory protein-1 beta, MIP-1β, MIP-1-beta, Act-2, AT744, G-26, HC21, LAG-1, LAG1, SCYA2, SCYA4 |
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