Interleukin 12 (IL-12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. The p40 subunit is shared with IL-23. IL-12 is produced by antigen-presenting cells, specifically dendritic cells, and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing the proliferation and cytotoxicity of NK and T cells.
| Alternative analyte names: | Interleukin 12, IL-12, IL12 |
| Cell types: | Monocyte/MΦ, mDC |
| Products: | Click here to see our portfolio of IL-12 (p70) products. |