Transforming growth factor β1 (TGF-β1) is secreted by many cells and controls functions such as cell growth, cell differentiation, proliferation, and apoptosis. The cytokine TGF-β1 is an important regulator of immune functions. Specifically for T cells, TGF-β1 promotes the differentiation of regulatory T cells, preventing IL-1- and IL-2-dependent proliferation of activated T cells, the activation of helper T cells, and cytotoxic T cells. TGF-β1 is secreted in a latent, biologically inactive form, non-covalently linked with a latency associated protein (LAP).
| Alternative analyte names: | Transforming growth factor β1, TGF-β1, TGF beta 1, latency associated peptide, LAP |
| Cell types: | T cell, Th1, Treg, Tfh, Monocyte/MΦ, Th17 |
| Products: | Click here to see our portfolio of TGF-β1 (Latent TGF-β1) products. |