Anti-mouse IL-12/-23 (p40) mAb (C17.8), azide free
Anti‑mouse IL‑12/‑23 (p40) mAb (C17.8), azide free
Content
Monoclonal antibody C17.8, unconjugated. Supplied at 1 mg/ml in PBS, free of preservatives.
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Analyte information
IL-12/-23 (p40)
| Analyte description | Interleukin 12 (IL-12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. IL-12 is produced by antigen-presenting cells, specifically dendritic cells, and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing the proliferation and cytotoxicity of NK and T cells. Interleukin-23 (IL-23) is a disulfide-linked heterodimer that consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells, and IL-23 is responsible for Th17 expansion and stabilization. Since both IL-12 and IL-23 heterodimers comprise the p40 subunit, capture immunoassays based on antibodies to p40 will detect both cytokines. Such assays can also detect p40 monomers and dimers. |
| Alternative names | Interleukin 12, IL-12, IL12, IL12A, IL12B, Il-12b, Il-12p40, Il12p40, p40 |
| Cell type | Monocyte/MΦ, mDC |
| Gene ID | 16160 |