ELISA PathRF: Human IL‑17A
ELISA PathRF: Human IL‑17A
Components
| Plate | Pre-coated ELISA strip plate (mAb MT44.6) |
| Detection mAb | MTR-5, biotin |
| Enzyme conjugate | Streptavidin-HRP enzyme conjugate |
| Standard | Recombinant human IL-17A ELISA standard |
| Substrate | TMB substrate for ELISA |
| Buffers/Solutions | RF-block diluent |
| Standard reconstitution buffer | |
| Streptavidin-HRP diluent | |
| Wash buffer concentrate | |
| Stop solution | |
| Also provided | Adhesive plate covers |
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Performance
| Standard range | 3.16-1000 pg/ml |
| Sensitivity | 1 pg/ml The lowest concentration that can be detected, but not necessarily quantified with precision and accuracy. This was determined by adding 2 standard deviations to the mean OD of background wells. |
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Analyte information
IL-17A
| Analyte description | Interleukin 17A (IL-17A) is a potent proinflammatory cytokine produced by activated Th17 (T helper 17) cells and certain cells belonging to the innate immune system. In mice, IL-17 has also been shown to be produced by activated CD8 T cells and γδ T cells. Th17 cells play an important role in autoimmune diseases and protection against bacteria and fungi. IL-17A acts on a broad range of cell types to induce the expression of cytokines, chemokines, and metalloproteinases. As a result, secretion of IL-17A promotes inflammatory responses, which leads to the recruitment of neutrophils, enhancement of antibody production, and activation of T cells. Increased expression of IL-17A is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It is also associated with asthma, psoriasis, cancer, and transplant rejection. |
| Alternative names | Interleukin 17A, IL-17A, IL17A, CTLA-8, CTLA8, IL-17, IL17, ILA17 |
| Cell type | Th17 |
| Gene ID | 3605 |