Components
Plate | Pre-coated ELISpot plate, white MSIP (mAbs MT31/88) |
Detection mAb | MT158, biotin |
Enzyme conjugate | Streptavidin-ALP |
Substrate | BCIP/NBT-plus |
Positive control | Anti-CD3 mAb (CD3-2) |
Co-stimulus | Anti-CD28 mAb (CD28-A) |
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Analyte information
IL-31
Analyte description | Interleukin 31 (IL-31) is a cytokine belonging to the IL-6 family. It is mainly secreted by activated T cells, especially in Th2 helper cells, mast cells, macrophages, and dendritic cells. IL-31 mainly acts in the skin, lung, intestine, and nervous system, facilitating cell-mediated immunity against pathogens. The receptor for IL-31 is found on e.g. keratinocytes and endothelial cells and can be upregulated on activated monocytes. However, IL-31 is considered a Th2-type cytokine with different functions than other Th2-type cytokines. In transgenic mice overexpressing IL-31, the cytokine induces pruritus and dermatitis resembling human atopic dermatitis (AD). In humans, IL-31 has been associated with AD, atopic and contact allergies, airway hypersensitivity, and inflammatory bowel disease. |
Alternative names | Interleukin-31, IL-31, IL31 |
Cell type | T cell, Tc, Th1, NK cell |
Gene ID | 386653 |