EYRAplex: Human Proinflammatory (8‑plex)
EYRAplex: Human Proinflammatory (8‑plex)
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Components
| Capture mAb | Capture bead mix: Human Proinflammatory (8-plex) |
| Detection mAb | Detection mAb mix: Human Proinflammatory (8-plex) |
| Standard | Standard mix A: EYRAplex human |
| Fluorophore conjugate | Streptavidin-PE |
| Buffers/Solutions | Assay diluent: EYRAplex |
| Streptavidin-PE diluent | |
| Wash buffer concentrate | |
| Also provided | 96-well plate (black) |
| Adhesive plate covers | |
| Black plate lid |
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Performance
| Analyte | LOD (pg/ml) | LLOQ (pg/ml) | Intra-assay CV(%) | Inter-assay CV(%) |
|---|---|---|---|---|
| IFN-γ | 0.1 | 3.7 | <5% | <15% |
| IL-1β | 0.1 | 2.7 | <5% | <15% |
| IL-6 | 0.2 | 2.6 | <5% | <15% |
| IL-8 (CXCL8) | 0.9 | 6.9 | <5% | <15% |
| IL-10 | 0.2 | 1.2 | <5% | <15% |
| IL-12 (p70) | 0.50 | 6.6 | <5% | <15% |
| IL-13 | 0.4 | 4.1 | <5% | <15% |
| TNF-α | 1.0 | 18.5 | <5% | <15% |
Average Recovery (%) in
| Analyte | Heparin plasma | RA plasma | Serum |
|---|---|---|---|
| IFN-γ | 85 | 79 | 88 |
| IL-1β | 90 | 92 | - |
| IL-6 | 89 | 99 | ND |
| IL-8 (CXCL8) | 104 | 97 | 109 |
| IL-10 | 84 | 91 | - |
| IL-12 (p70) | - | - | 81 |
| IL-13 | 89 | 100 | 71 |
| TNF-α | 94 | 100 | 72 |
Representative standard curves for EYRAplex: Human Proinflammatory (8-plex).
Publications (0)
Analyte information
IFN-γ
| Analyte description | Interferon-γ (IFN-γ) is the only type II interferon. This proinflammatory cytokine is secreted by activated T cells and NK cells. It activates macrophages and endothelial cells and regulates immune responses by affecting APCs, T cells, and B cells. Production of IFN-γ by helper T cells and cytotoxic T cells is a hallmark of the Th1-type phenotype. Thus, high-level production of IFN-γ is typically associated with effective host defense against intracellular pathogens. |
| Alternative names | Interferon-γ, Interferon-gamma, IFN-γ, IFN-gamma, IFN-g, IFNg |
| Cell type | T cell, Tc, Th1, NK cell |
IL-1β
| Analyte description | Interleukin 1ß (IL-1ß) is a proinflammatory cytokine and inducer of acute phase responses. IL-1ß is produced primarily by monocytes, macrophages, and dendritic cells after induction by microbes. |
| Alternative names | Interleukin-1ß, IL-1ß, IL-1F2, Interleukin-1beta, IL-1 beta, IL1b, Interleukin-1 beta |
| Cell type | Monocyte/MΦ, mDC |
IL-6
| Analyte description | Interleukin 6 (IL-6) is a pleiotropic cytokine produced by many different cell types and plays a role in a wide range of functions, such as immune responses, acute-phase reactions, and hematopoiesis. Among other things, it augments antibody production from activated B cells in vitro. |
| Alternative names | Interleukin 6, IL-6, IL6, IFB-B502, BSF-2, BCDF |
| Cell type | B cell, Monocyte/MΦ, mDC |
IL-8 (CXCL8)
| Analyte description | Interleukin 8 (IL-8) is a proinflammatory cytokine produced by different types of cells, including monocytes, macrophages, and endothelial cells. Inflammatory stimuli, such as LPS, strongly induce IL-8 production by monocytes. |
| Alternative names | Interleukin-8, IL-8, IL8, CXCL8 |
| Cell type | T cell, Treg, Tfh, Monocyte/MΦ, mDC |
IL-10
| Analyte description | Interleukin 10 (IL-10) is a pleiotropic cytokine produced by activated T cells and monocytes. It can modulate the functions of immune responses in both a stimulatory and an inhibitory way. IL-10 is thereby involved in the regulation of immune reactions and inflammatory responses. |
| Alternative names | Interleukin-10, IL-10, IL10 |
| Cell type | T cell, Treg, Monocyte/MΦ, mDC |
IL-12 (p70)
| Analyte description | Interleukin 12 (IL-12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. The p40 subunit is shared with IL-23. IL-12 is produced by antigen-presenting cells, specifically dendritic cells, and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing the proliferation and cytotoxicity of NK and T cells. |
| Alternative names | Interleukin 12, IL-12, IL12 |
| Cell type | Monocyte/MΦ, mDC |
IL-13
| Analyte description | Interleukin 13 (IL-13) is produced by Th2-type cells, mast cells, and NK cells in response to activation. It regulates the secretion of IgE by B cells and the Th2-type cell development and suppresses inflammatory responses by regulation of macrophage function. |
| Alternative names | Interleukin 13, IL-13, IL13 |
| Cell type | T cell, Th2, Treg |
TNF-α
| Analyte description | Tumor necrosis factor (TNF), also known as TNF-α, is produced by many different cell types, e.g., monocytes, macrophages, T cells, and B cells. Among the many effects of TNF-α are protection against bacterial infection, cell growth modulation, immune system regulation, and involvement in septic shock. |
| Alternative names | Tumor necrosis factor-α, TNF-α, TNF-alpha, TNF-a, TNFa, Tumor necrosis factor-alpha, TNF |
| Cell type | T cell, Tc, Th1, Th2, Th17, Tfh, Monocyte/MΦ |