FluoroSpot Path: SARS‑CoV‑2 (S1scan+SNMO) Human IFN‑γ/Granzyme B
FluoroSpot Path: SARS‑CoV‑2 (S1scan+SNMO) Human IFN‑γ/Granzyme B
Components
| Plate | Pre-coated FluoroSpot plate (mAbs 1-D1K and MT34B6) |
| Detection mAbs | Anti-IFN-γ mAb (7-B6-1), BAM |
| Anti-Granzyme B (MT28), biotin | |
| Fluorophore conjugates | Anti-BAM mAb, 490 |
| SA-550 | |
| Buffer/Solution | FluoroSpot enhancer |
| Positive control | Anti-CD3 mAb (CD3-2) |
| Co-stimulus | Anti-CD28 mAb (CD28-A) |
| Peptide pools | SARS-CoV-2 (S1), scanning |
| SARS-CoV-2 (SNMO), human |
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Analyte information
IFN-γ
| Analyte description | Interferon-γ (IFN-γ) is the only type II interferon. This proinflammatory cytokine is secreted by activated T cells and NK cells. It activates macrophages and endothelial cells and regulates immune responses by affecting APCs, T cells, and B cells. Production of IFN-γ by helper T cells and cytotoxic T cells is a hallmark of the Th1-type phenotype. Thus, high-level production of IFN-γ is typically associated with effective host defense against intracellular pathogens. |
| Alternative names | Interferon-γ, Interferon-gamma, IFN-γ, IFN-gamma, IFN-g, IFNg, IFG, IFI, IMD69 |
| Cell type | T cell, Tc, Th1, NK cell |
| Gene ID | 3458 |
Granzyme B
| Analyte description | Granzyme B is a serine protease released by the cytoplasmic granules within cytotoxic T cells and NK cells. Granzyme B will act together with perforin and other cytotoxic mediators to induce target cell death by apoptosis. |
| Alternative names | Granzyme B, GzmB, GrB, GrzB, C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT |
| Cell type | T cell, Tc, Th1, NK cell |
| Gene ID | 3002 |