Components
Plate | Pre-coated FluoroSpot plate (mAbs 1-D1K and 9D7) |
Detection mAbs | Anti-IFN-γ mAb (7-B6-1), BAM |
Anti-IL-10 mAb (12G8), biotin | |
Fluorophore conjugates | Anti-BAM mAb, 490 |
SA-550 | |
Buffer/Solution | FluoroSpot enhancer |
Positive control | Anti-CD3 mAb (CD3-2) |
Co-stimulus | Anti-CD28 mAb (CD28-A) |
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Performance
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Publications (8)
Analyte information
IFN-γ
Analyte description | Interferon-γ (IFN-γ) is the only type II interferon. This proinflammatory cytokine is secreted by activated T cells and NK cells. It activates macrophages and endothelial cells and regulates immune responses by affecting APCs, T cells, and B cells. Production of IFN-γ by helper T cells and cytotoxic T cells is a hallmark of the Th1-type phenotype. Thus, high-level production of IFN-γ is typically associated with effective host defense against intracellular pathogens. |
Alternative names | Interferon-γ, Interferon-gamma, IFN-γ, IFN-gamma, IFN-g, IFNg, IFG, IFI, IMD69 |
Cell type | T cell, Tc, Th1, NK cell |
Gene ID | 3458 |
IL-10
Analyte description | Interleukin 10 (IL-10) is a pleiotropic cytokine produced by activated T cells and monocytes. It can modulate the functions of immune responses in both a stimulatory and an inhibitory way. IL-10 is thereby involved in the regulation of immune reactions and inflammatory responses. |
Alternative names | Interleukin-10, IL-10, IL10, CSIF, GVHDS, IL-10A, TGIF |
Cell type | T cell, Treg, Monocyte/MΦ, mDC |
Gene ID | 3586 |
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