Components
Plate | Pre-coated ELISpot plate, white MSIP (mAb IL17-I) |
Detection mAb | MT2270, biotin |
Enzyme conjugate | Streptavidin-HRP |
Substrate | ELISpot substrate: TMB for HRP |
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Analyte information
IL-17A
Analyte description | Interleukin 17A (IL-17A) is a potent proinflammatory cytokine produced by activated Th17 (T helper 17) cells and certain cells belonging to the innate immune system. In mice, IL-17 has also been shown to be produced by activated CD8 T cells and γδ T cells. Th17 cells play an important role in autoimmune diseases and protection against bacteria and fungi. IL-17A acts on a broad range of cell types to induce the expression of cytokines, chemokines, and metalloproteinases. As a result, secretion of IL-17A promotes inflammatory responses, which leads to the recruitment of neutrophils, enhancement of antibody production, and activation of T cells. Increased expression of IL-17A is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It is also associated with asthma, psoriasis, cancer, and transplant rejection. |
Alternative names | Interleukin 17A, IL-17A, IL17A, Ctla-8, Ctla8, IL-17, Il17 |
Cell type | Th17 |
Gene ID | 16171 |