Anti-human IL-31 mAb (MT158), biotin

Anti-human IL-31 mAb (MT158), biotin

3530-6-250

Publications: 4
Documents
Bulk or custom format
Validated for our assays.

Content

Monoclonal antibody MT158, biotinylated. Supplied at 0.5 mg/ml in PBS with 0.02% sodium azide.

In stock

Delivery 4-9 business days

Shipping $0

Complementary products

Complementary products
1 / 1

Product specifications

Intended use

This monoclonal antibody enables specific detection of human IL-31 in immunoassays such as ELISpot and ELISA.

Serum/Plasma samples

Recommendation

MT158 is recommended as detection mAb in ELISpot and ELISA in combination with capture mAbs MT31/88 (product code 3530-3).

Product details

ProductAnti-human IL-31 mAb (MT158), biotin
ApplicationELISpot, ELISA
AnalyteIL-31
AntibodyMT158
ConjugateBiotin
ClonalityMonoclonal
ImmunogenRecombinant human IL-31
HostMouse
IsotypeIgG1
ReactivityHuman
SpecificityNative and recombinant human IL-31
PurificationPurified from in vitro cultures by protein G affinity chromatography.
BiotinylationBiotinylated through reaction with a N-hydroxysuccinimide ester of biotin.
Concentration0.5 mg/ml
Supplied inPBS with 0.02% sodium azide. Sterile-filtered (0.2 µm).
ContentsMonoclonal antibody MT158, biotinylated. Supplied at 0.5 mg/ml in PBS with 0.02% sodium azide.

Shipping and Storage

ShippingShipped at ambient temperature.
StorageStore product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/thawing.
Shelf lifeAt least 18 months from date of receipt.

Tutorial, Published December 28, 2023

Incubation strategies for success in ELISpot and FluoroSpot
We've made a handy table summarizing incubation times for different analytes to make your research planning for the ELISpot and FluoroSpot assay a little easier.
Loading publications...

IL-31

Analyte description

Interleukin 31 (IL-31) is a cytokine belonging to the IL-6 family. It is mainly secreted by activated T cells, especially in Th2 helper cells, mast cells, macrophages, and dendritic cells. IL-31 mainly acts in the skin, lung, intestine, and nervous system, facilitating cell-mediated immunity against pathogens. The receptor for IL-31 is found on e.g. keratinocytes and endothelial cells and can be upregulated on activated monocytes. However, IL-31 is considered a Th2-type cytokine with different functions than other Th2-type cytokines. In transgenic mice overexpressing IL-31, the cytokine induces pruritus and dermatitis resembling human atopic dermatitis (AD). In humans, IL-31 has been associated with AD, atopic and contact allergies, airway hypersensitivity, and inflammatory bowel disease. 
 

Alternative namesInterleukin-31, IL-31, IL31
Cell typeT cell, Tc, Th1, NK cell
Gene ID386653
1 / 2