Anti-mouse IL-17A mAb (TC11-18H10), azide free

Anti‑mouse IL‑17A mAb (TC11‑18H10), azide free

3521-0N-500

Publications: 4
Documents
Questions?
Validated for our assays.

Content

Monoclonal antibody TC11-18H10, unconjugated, Supplied at 0.5 mg/ml in PBS, free of preservatives.

In stock

Delivery 4-9 business days

Shipping $0

Product specifications

Intended use

This monoclonal antibody enables neutralization of mouse IL-17A bioactivity.

Serum/Plasma samples

Recommendation

It is recommended to establish the optimal antibody concentration for the assay system used.

Product details

ProductAnti-mouse IL-17A mAb (TC11-18H10), azide free
ApplicationNeutralization
AnalyteIL-17A
AntibodyTC11-18H10
ConjugateUnconjugated
ClonalityMonoclonal
ImmunogenRecombinant mouse IL-17A
HostRat
IsotypeIgG1
ReactivityMouse
Specificity

Native and recombinant mouse IL-17A

Purification

Purified from in vitro cultures by protein G affinity chromatography.

Concentration0.5 mg/ml
Supplied in

PBS, free of preservatives. Sterile-filtered (0.2 µm).

Contents

Monoclonal antibody TC11-18H10, unconjugated, Supplied at 0.5 mg/ml in PBS, free of preservatives.

Shipping and Storage

Shipping

Shipped at ambient temperature.

Storage

Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/thawing.

Shelf lifeAt least 12 months from date of receipt.
Loading publications...

IL-17A

Analyte description

Interleukin 17A (IL-17A) is a potent proinflammatory cytokine produced by activated Th17 (T helper 17) cells and certain cells belonging to the innate immune system. In mice, IL-17 has also been shown to be produced by activated CD8 T cells and γδ T cells. Th17 cells play an important role in autoimmune diseases and protection against bacteria and fungi. IL-17A acts on a broad range of cell types to induce the expression of cytokines, chemokines, and metalloproteinases. As a result, secretion of IL-17A promotes inflammatory responses, which leads to the recruitment of neutrophils, enhancement of antibody production, and activation of T cells. Increased expression of IL-17A is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It is also associated with asthma, psoriasis, cancer, and transplant rejection.

Alternative namesInterleukin 17A, IL-17A, IL17A, Ctla-8, Ctla8, IL-17, Il17
Cell typeTh17
Gene ID16171
1 / 3