Components
Capture mAb | 11B11 |
Detection mAb | BVD6-24G2, biotin |
Enzyme conjugate | Streptavidin-ALP |
Standard | Recombinant mouse IL-4 ELISA standard |
Buffer/Solution | Standard reconstitution buffer |
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Performance
Standard range | 4-400 pg/ml |
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Analyte information
IL-4
Analyte description | Interleukin 4 (IL-4) is produced primarily by Th2 cells, mast cells, eosinophils, and basophils. IL-4 was first identified to costimulate B cell growth; the cytokine is essential for B cell secretion of IgE and augments the production of IgG1 in vivo. In addition to regulating B cell growth and immunoglobulin secretion, IL-4 also affects T cells. In vitro, IL-4 promotes T cell growth and can induce cytolytic T cell activity. IL-4 also induces the differentiation of naive CD4 T cells into Th2 cells, which are characterized by their capacity to secrete the cytokines IL-4, IL-5, and IL-10 upon activation, while simultaneously inhibiting the generation of Th1 cells. |
Alternative names | Interleukin 4, IL-4, IL4, BCGF-1, BSF-1, Il-4 |
Cell type | T cell, Th2, Treg |
Gene ID | 16189 |
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